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demonstrated in KO mice that the regulation of -cell number and function by GLP-1 depends on the cAMP/PKA mediated-induction of insulin-like growth factor-1 receptor (IGF-1R) expression and the increased activity of insulin-like growth factor 2 (IGF-2)/IGF-1R by an autocrine mode of action [25]
7 The primary placebo-controlled trial involved adults without diabetes, with an average starting age of 46 years and a female majority of 74%
Cell 134 , 866876 (2008)
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