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despite lacking these potentially valuable activities, it is the only drug that has been continuously used for the timely and domiciliary management of COVID-19 without undergoing any safety evaluation although its adverse effects could even increase depending on specific conditions, particularly those occurring in at risk COVID-19 population

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10.1016/j.cell.2014.05.052 25 CryanJ

We highlight the clinical implications of disturbances in physiological brainheart communication for various clinical conditions, including Takotsubo syndrome resulting from emotional stress or from brain disorders, cardiac complications after stroke (so-called strokeheart syndrome), and cognitive dysfunction in patients with cardiac diseases such as heart failure and atrial fibrillation