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Specifically, IKE boasts a solubility that is three times higher than erastin, and it exhibits a remarkable 50-fold reduction in the Lethal Concentration 50 (LC50) for tumor cells, indicating a significantly enhanced antitumor potency ( DPI2, a FIN (ferroptosis-inducing compound), which does not inhibit GPx4 activity but specifically inhibits SLC7A11 expression, consumed 90% of the GSH in BjeLR cells compared to the untreated group
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Specifically, competition for nutrients or cell-intrinsic programming between cancer cells and immune cells induces nutrient deficiency and metabolic reprogramming of immune cells, leading to modulation of antitumor immunity 128,129
