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In LPS-induced sepsis, CUL5 interacts with TRAF6 and promotes its K63-linked polyubiquitination at Lys63, leading to the activation of NF-B and MAPK pathways, enhanced expression of inflammatory genes, and subsequent production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF- (122)

Alcohol-Abuse Antidote L-cysteine has been suggested as an antidote for the negative effects of excessive alcohol intake , such as liver damage or hangover

Lack of involvement of glutamate-induced excitotoxicity in MPP+ toxicity in striatal dopaminergic terminals: possible involvement of ascorbate

The spray voltage was 3.7 kV