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Secondly, they act in an event-driven way, that is, a single molecule can catalyze multiple rounds of degradation, achieve substoichiometric efficiency and reduce dose requirements [19,20,21,22]
Among four candidates including atorvastatin, lovastatin, rosuvastatin, and pravastatin, only atorvastatin could lead to ferroptosis in human cardiomyocytes (HCM) and murine skeletal muscle cells (C2C12), instead of human umbilical vein endothelial cell (HUVEC)
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