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In fact, nearly one third of all the NTS GLP-1-producing neurons send ascending fibers to the VTA and the NAc (core and shell regions) (Dossat et al., Figure 1 GLP-1R-driven activation of the mesolimbic neurons On the basis of immediate early gene expression analysis it seems that GLP-1 or its analogs can increase neuronal activity in the mesolimbic system

Neuronal inflammation was also attenuated by suppression of the HMGB1 (high mobility group box-1)/TLR4 (toll-like receptors)/NLRP3 (nod-like receptor protein) inflammasome [52]

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