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However, plasma concentration of citrulline, synthesized in the small intestinal epithelium as part of the urea cycle and serving as a functional readout of IEC mitochondrial function, was decreased in ClpP IEC mice, in line with previous results from Hsp60 IEC mice (64) ( Figure 5D )

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BMJ 352:i610 Aronoff S, Rosenblatt S, Braithwaite S et al (2000) Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study