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For example, in the tirzepatide study mentioned, 1.7% of placebo recipients reported vomiting compared to 8.3% of those taking 5mg doses, 10.7% of those taking 10mg doses, and 12.2% taking 15mg doses
Doctors often start patients on a low dose and raise it slowly to help the body adjust
Research Snapshot: Current State of Research Semaglutide has been examined extensively in GLP-1 receptor pharmacology, glucose-regulation research, appetite and gastric-emptying studies, cardiovascular-outcome research, body-weight trials, kidney-outcome research, and peptide-formulation studies
doi: 10.1016/j.phrs.2021.105874
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