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We previously produced the App NL-G-F/NL-G-F -KI ( App NL-G-F ) mouse strain using genomic DNA of introns 15 to 17 of mouse APP, which humanized the A sequence, and introduced KM670/671NL (Swedish), I716F (Iberian), and E693G (Arctic) mutations 41

Slowlyand we mean slowly depress the plunger, allowing the BAC water to gently run down the side of the glass and pool at the bottom