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Although massive germ-cell death had not yet been triggered, changes in GPX4 and ACSL4 indicated an elevated susceptibility to ferroptosis at this stage

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A landmark meta-analysis found that weight reduction of 5-10% resulted in spontaneous ovulation restoration in 55-100% of women with anovulation related to obesity

Summary Keywords ferroptosis, gut microbiota, polycystic ovary syndrome, traditional Chinese medicine compound formulas, traditional Chinese medicine monomers Citation Lv Y, Li D, Ding N and Kuang H (2026) The role of gut microbiota mediated ferroptosis in PCOS and the therapeutic potential of Chinese herbal medicine