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IGF-1 LR3 is investigated in preclinical research for IGF-1R signaling, PI3K/Akt/mTOR pathway activation, skeletal muscle protein synthesis, and metabolic pathway research
These proteins recruit the adaptor proteins optineurin (OPNT) and calcium binding and coiled-coil domain (CALCOCO), etc., which subsequently bind to LC3 (Reference Narendra and Youle53, Reference Padman, Nguyen and Uoselis54)
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