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While headline pharmaceutical research and development (R&D) returns have improved for the third consecutive year, reaching a 7.0 per cent internal rate of return (IRR) in 2025, this recovery is largely driven by a few mega-blockbuster programmes, notably glucagon-like peptide receptor agonists (GLP-1s) and GLP-1 combinations with gastric inhibitory polypeptide-based drugs (GIPs) in obesity, masking broader R&D pressures

Studies suggest that 20 50% of the total weight loss in individuals using semaglutide is due to muscle mass reduction, which is particularly evident in those with significant initial body weight

Your body needs all three macronutrients to survive, but modern diets and lifestyles tend to skew the balance, often heavily in favor of carbohydrates

Call a doctor