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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide

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Female patients were predominant in both cohorts, with a greater proportion in the Wegovy cohort than in the Zepbound cohort (82.65% vs 81.66%, p = .2229)

However, the introduction of melanotan 2 nasal sprays offers researchers an additional option for study designs in which injections are unsuitable for reasons including: Test subjects uncomfortable with self-administering injections Fear of needles Injection site pain Poor test subject compliance Although an MT-II nasal spray has not been specifically evaluated in clinical trials, research supports the compatibility of the MT-II peptide with an intranasal format, along with a long track record of delivering peptides and protein intranasally [3]