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Particularly for tirzepatide, in the mixed effects model on a subset of the data with therapy duration greater than 180 days, there is a positive coefficient with therapy duration and weight regain after cessation with a significant P value

These medications can be incredibly effective at helping patients lose significant amounts of weight, often very quickly

These dual-pathway effects may explain why combination therapies show superior metabolic outcomes in early clinical data

The good news here is that we are learning more and more about why GLP-1s lead to side-effects, and in the future may be to develop even more targeted treatments