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Eligible participants had the New York Heart Association (NYHA) functional classes II to IV, a six-minute walking distance (6MWD) of 100 m, and a minimum of increased filling pressure, increased N-terminal pro-brain natriuretic peptide (NT-proBNP) levels with structural echocardiographic irregularities, or a previous history of heart failure-related hospital admission in the prior year with current diuretic therapy

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Most side effects begin improving around day ten to fourteen, though individual variation is significant and genetic factors may influence both onset and severity

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