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Six healthy volunteers with similar age and biological sex distribution as the COVID-19 patients were recruited to compose the control group from 27th to 31st July 2020

TNF is a crucial mediator of this pathology. TNF and another pro-inflammatory substance called interleukin 1, produce products like reactive oxygen species that damage both the filters and the elastic cells that wrap around their exterior

Care 10, R41

In immunocompetent patients, the occurrence of hyperinsulinemia serves to enhance the innate immune response and enhance the antiviral effector response of CD8 T cells, as insulin receptor and CD28 signaling converge on PI3K [247, 248]