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Furthermore, large scale epidemiological studies are needed that investigate the effects of GLP-1 receptor agonists on the risk of hyperkalemia in people with type 2 diabetes, with only a few small clinical studies suggesting plausible mechanisms for increased potassium excretion.2425 GLP-1 receptor agonists might lead to increased potassium secretion owing to enhancement in sodium delivery to the cortical collecting duct and altered tubular electronegativity.2526 Additionally, long term kidney preservation by SGLT-2 inhibitors or GLP-1 receptor agonists might contribute to reduced hyperkalemia risks
Saxena, A
This is the most widely used ratio because it creates manageable volumes for common dose ranges
