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Warnings and precautions include severe gastrointestinal adverse reactions, acute kidney injury, acute gallbladder disease, acute pancreatitis, serious hypersensitivity reactions, increased risk of hypoglycemia with concomitant use of an insulin secretagogue or insulin, diabetic retinopathy complications in patients with type 2 diabetes, suicidal behavior and ideation, and pulmonary aspiration during general anesthesia or deep sedation

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This antibody-driven mechanism explains why some users develop injection site reactions only after weeks or months of treatment, long after the initial adaptation period should have passed