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Oehninger, S., Franken, D

The rectal suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts at body temperature

(1) modulating antigen presentation to lymphocytes, thereby influencing cytokine production and type of response (cellular or humoral) that develops, (2) enhancing proliferation of lymphocytes, thereby increasing magnitude of response, (3) enhancing killing activity of cytotoxic T cells and NK cells, and (4) regulating apoptosis, thereby maintaining control of the immune response