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Chronic studies in rats given 200 mg/kg body weight per day for 104 weeks, dogs given 20 mg/kg PO x 84 days, cats given 40-65 mg/kg for 118 days did not produce any signs of toxicity (blood testing, liver histology)
The authors conducted experiments to identify the most effective conditions for using Sacha inchi shells for this purpose
Berberine Activates Bitter Taste Responses of Enteroendocrine STC-1 Cells. Molecular and Cellular Biochemistry, vol
The studied dosing starts low (about 2 mg weekly) and is increased roughly every four weeks to a target dose, with 12 mg being the highest dose in the main Phase 2 obesity trial
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