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(PubMed) Leung AM, Avram AM, Brenner AV, et al
The increased amount of GABA then downregulates the GABA receptors, making the net effect less of an inhibitory signal.[ref] GABA can also be metabolized into creatine, and an increase in both GABA and creatine is found in people with dysfunction in the ALDH5A1 gene
Analysis of CTCs obtained from patients and mouse models during the resting phase using scRNA-seq reveals significant upregulation of mitotic genes, which may contribute to the enhanced metastatic potential of CTCs
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