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After reaching the liver via the portal vein, some of these toxins are metabolized and detoxified by the liver, while others are excreted through the kidneys

Correlations have been made with mutations in filaggrin (a key protein in skin barrier function)

Chen Y, Zhang Q, Liu H, Lu C, Liang CL, Qiu F, Han L, Dai Z (2018) Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4+Foxp3+ regulatory T cells

19,36,38 To explore which co-repressor may be recruited by the TRIM28 complex, H3K27ac and H3K9me3 profiles were analyzed in both control and Trim37 ko3 PGCs using CUT&Tag (Supplementary information, Fig