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Nelson ED, Kavalali ET, Monteggia LM

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Preclinical studies suggest ALA may help defend neurons against oxidative stress, support synaptic function, and maintain healthy levels of glutathione, a critical antioxidant in brain cells.12 25 Importantly, ALA can cross the blood-brain barrier, making it a promising candidate for addressing conditions where oxidative stress or mitochondrial dysfunction play a role

Studies with transdermal forms did not show elevations of reduced glutathione either