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Anita Skrtic, [email protected] This article was submitted to Translational Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

From there, the trial product estimand and the treatment policy estimand were used to assess the efficacy of the treatment in all randomly assigned participants

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