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Semaglutide has an isoelectric point at pH 5.4, meaning the molecule carries no net charge at this pH and is most prone to aggregation
A generic manufacturer could theoretically produce a different semaglutide formulation today without violating the expired composition patent, but they'd need to design around the active formulation patents, complete FDA approval (a 2-3 year process), and avoid triggering patent infringement litigation
The World Health Organization (WHO) and other experts say more research is needed
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