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Of note, even before the introduction of the newer classes of medications, multifactorial, target-driven therapies addressing glycaemic, blood pressure and lipid control that incorporated reninangiotensin system blockade, the use of statins and attention to lifestyle factors significantly reduced the progression to end-stage kidney disease by about 50% in people with type 2 diabetes, hypertension and microalbuminuria

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Researchers commonly hold a step longer if GI side effects are not tolerated rather than skip ahead

no liver safety concerns have been identified