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Achieving these stringent endpoints, as outlined in the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE-II) consensus ( Research into mucosal healing has highlighted pathways involving interleukin-20 (IL-20), claudin-2 (CLDN2), and notoginsenoside R1 (NGR1) ( Figure 1 illustrates the differences in immune cell distribution within the intestinal crypts under homeostatic conditions compared with the inflammatory microenvironments of CD and UC
15% Patients lost an average of 15% of their body weight in ~1 year
Novo Nordisk spokesperson Allison Scheider says the company takes all reports about new side effects "very seriously," but added that this class of drugs has been used for more than 15 years
Some patients and providers pursue a 'treatment, then maintenance' strategy: use semaglutide intensively for 12-18 months to achieve weight loss goals, then step down to a lower maintenance dose or switch to less frequent dosing
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