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Esses cidos graxos ativados possuem baixa capacidade de penetrao mitocondrial , necessitando de um carreador fisiolgico funo desempenhada pela L-carnitina , que os direciona para a oxidao energtica , reduzindo sua disponibilidade para formar novos triglicerdeos
Additional modifications were produced to improve the original discovery, of which four emerged as most logical candidates for drug development, including GHRP-6 (His-D-Trp-Ala-Trp-D-Phe-Lys-NH 2 ), Hexarelin (His-D-Mrp-Ala-Trp-D-Phe- Lys-NH 2 ), GHRP-2 (D-Ala-D--Nal-Ala-Trp-D-Phe-Lys) or pralmorelin which was most potent, and ipamorelin (Aib-His- D-2-Nal-D-Phe-Lys-NH 2 ) which persisted in the circulation longer than the other GHRPs 3
10.1042/bj20111451 31 LenardoM
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