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doi: 10.1016/j.pharmthera.2013.09.006 235 RyuG.ShinH.-W

xCT (Xc cystine/glutamate antiporter) is an important component of antioxidant activity in vivo , which is associated with glutathione synthesis (100)

Rintatolimod: toll-like receptor 3 (TLR3) agonist for ME/CFS therapy By activating TLR3, rintatolimod triggers a type I interferon-mediated antiviral response, which upregulates effector proteins such as 2-5 oligoadenylate synthetase and protein kinase R to degrade viral ribonucleic acid (RNA) and inhibit translation, collectively enhancing the hosts antiviral defense

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