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Its ability to improve depressive symptoms without adversely affecting sexual function or body weight, combined with its application in smoking cessation and seasonal affective disorder, underscores its value in a comprehensive mental health treatment plan

ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population ( Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide ( Mechanisms related to cardiovascular effects of GLP-1 receptor agonists The cardiovascular effects of GLP-1 receptor agonists in CVOTs can be attributed to several mechanisms

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"Real-world studies, like STEER, provide us with important insights into how treatments may serve patients outside of controlled clinical trials as we continue to learn more about the benefits of Wegovy beyond weight management." Additionally, in all treated people, regardless of any gaps in their treatment, people treated with Wegovy experienced fewer events of heart attack, stroke and cardiovascular-related death than people treated with tirzepatide