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Thus, in humans, GLP-1 action appears to be predominantly functional and anti-apoptotic rather than proliferative ( FIGURE 3 Both peripherally secreted GLP-1 and pharmacologic GLP-1RAs can cross the bloodbrain barrier (BBB) or interact with circumventricular organs, suggesting that peripheral administration is sufficient to reach CNS targets
Clinical Evidence: The STEP Program The STEP clinical trial program is the most relevant evidence base for semaglutide's weight management indication
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