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Hydration status, sleep quality, and stress levels also modulate GLP-1 receptor sensitivitychronically stressed or sleep-deprived patients often see slower initial results until those factors improve
A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)
Nonetheless, it is getting frequently prescribed for increasing muscle mass and putative, unproven , anti-aging benefit
However, oral semaglutide contains an absorption enhancer that may enter breast milk with unknown effects, so only injectable formulations are considered appropriate during breastfeeding
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