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PK describes how the body absorbs, distributes, metabolizes and eliminates the compound (ADME)
In a recent work by Corradini et al., variants of genes related to iron metabolism were shown to be associated with hyperferritinemia and more severe NAFLD (58)
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Thus, the authors demonstrate the presence of GSTM1-1 in liver and conclude that the alkylation and potential irreversible inactivation of this isoform in vivo could contribute to an understanding of the hepatotoxicity associated with zileuton [55]
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