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KPV's anti-inflammatory contribution is relevant here: synovial inflammation is a consistent feature of chronic joint stress models, and the reduction of IL-1 and TNF- that KPV demonstrates in cell culture models would be a logical correlate in a joint-stress research context [7]

The majority of the published studies on nanocarriers (Table III) lack thorough investigation of the capability of the nanocarriers to bind to the targeted transporter and evidence that the nanocarrier endocytosis or transcytosis is mediated by binding to the transporter

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