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In the trial mentioned above, one year after stopping the GLP-1 medication, participants also saw: Blood pressure levels go back up C-reactive protein levels (an indicator of inflammation) increase VLDL cholesterol (a type that leads to hardened arteries) goes up Triglycerides (a type of blood fat) go up Hemoglobin A1c increases (meaning the level of sugar in the blood) At high levels, these health markers are associated with conditions like type 2 diabetes, obesity, hypertension, and heart disease, to list a few

The authors attribute this shift to an imbalance between endothelium-derived relaxing factors (EDRFs)nitric oxide, prostacyclin, endothelium-derived hyperpolarizing factors, and natriuretic peptidesand endothelium-derived contracting factors (EDCFs), including endothelin-1, thromboxane A2, reactive oxygen species, and Rho-kinase signaling

Wang Y, Kim NS, Haince J-F, Kang HC, David KK, Andrabi SA, et al