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As increased BMI impairs GLP-1 secretion and aggravates insulin resistance, the supraphysiological infusions of GLP-1 may act as a positive feedback signal in obese patients to improve insulin sensitivity and reduce chronic obesity
They can also be more painful and more prone to injection site reactions
7, Ghezzi, P
Side Effects Common side effects Nausea Vomiting Diarrhea Stomach pain Loss of appetite Serious but less common side effects Risk of pancreatitis Gallbladder issues (gallstones, inflammation) Kidney problems (from dehydration due to vomiting/diarrhea) Potential increased risk of thyroid C-cell tumors (based on animal studies) Patients should report severe or unusual symptoms to their healthcare provider immediately
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