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Semaglutide (found in Ozempic and Wegovy) activates only GLP-1 receptors, while tirzepatide (found in Mounjaro and Zepbound) targets both GLP-1 and GIP receptors for a dual-action mechanism
Semaglutide produced 14.9% mean weight loss in STEP-1 at 68 weeks
Even 2 to 3 sessions per week of strength training can make a meaningful difference in breaking through a plateau
That's potentially due to improved body composition quality, so more lean muscle mass preservation, less visceral fat, and better metabolic flexibility
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