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Moreover, an open, single-arm, first-in-human trial of PU-H71 in patients with advanced solid tumors showed that the incidence of grade 2 adverse events such as common nausea, headache, and fatigue was extremely low, and only one patient exhibited a grade 3 adverse event (vomiting) that could be related to PU-H71

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We also review the literature on cutaneous melanoacanthoma with special emphasis on the multifocal lesions

These therapeutic effects occur after the medication has entered systemic circulation , not during the absorption phase, which means that the presence or absence of food in the gastrointestinal tract at the time of injection is irrelevant to the drug's pharmacological activity