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Another unique aspect of CHIVA is that rather than attempting to completely eliminate all reflux, as in other surgical methods, CHIVAs goal is interruption of venous hypertension at its source, higher up in the venous system (Mowatt-Larssen 2010
Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]
Quality and formulation Each vial is lyophilized to maintain stability and support long-term storage under proper laboratory conditions
