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Patients who have been told to "just live with it" are understandably open to trying something that offers a plausible biological mechanism and a sense of agency, even without a full evidence base
These aggressive protocols typically run shorter durations
Decades of peer-reviewed research support nicotinamide for strengthening the barrier and refining tone, and glutathione for protecting against free radicals and uneven pigmentation
But understanding what each phase feels like, what to expect, and when to adjust is what separates researchers who get results from those who quit early
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