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Vitamin B12 deficiency may also occur in people who have had intestinal surgery, including weight loss surgery

The largest increases in first-time CVD diagnosis following first-time GLP-1 RA prescription were seen in the group of people having overweight or BMIs between 27 to 30 (34.5% increase from 2020 to 2024)

In clinical trials, patients taking semaglutide GLP-1 over 68 weeks have been able to achieve weight loss of up to 10 to 20% of their total body weight