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The most frequently reported cardiovascular risk factors were hypertension and dyslipidemia (4,627 (73.9%) participants had hypertension and 4,237 (67.7%) participants had dyslipidemia) (Supplementary Table 2)
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Ultimately, a Cu(I)-catalyzed coupling-cyclization enabled the formation of the tricyclic structure of the potent DPP-4 inhibitor 44 (Figure 6) (116)
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