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Replacing the pyrazole methyl with chlorine and the p-chlorophenyl with a trifluoromethyl-BCP enhances metabolic stability, cellular penetration and safety while improving target engagement

Of the patients who switched medications, 8 in 10 switched to AOM semaglutide

Preclinical studies have shown that GIP may reduce body weight by reducing food intake and increasing energy consumption, and in combination with GLP-1 receptor agonists, may have a greater effect on patients' blood glucose and body weight

For example, about 77% of the propensity-matched cohort were white, and 70% were female, meaning that future studies could include more diversity among participants