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I have many patients who just flat-out refuse injections, no matter what the benefit might be. Available therapies contain two active ingredients that mimic the GLP-1 hormone in our bodies: semaglutide, which targets the GLP-1 receptors that regulate blood sugar, digestion and hunger
actual schedules vary by trial arm and protocol): Starting dose: 2 mg once weekly Escalation: doses increased incrementally (e.g., to 4 mg, 8 mg, and up to 12 mg) at intervals of approximately four weeks Maintenance dose: up to 12 mg once weekly in some trial arms These figures are provided for educational context only and must not be used to guide self-dosing
These compounds significantly improved depressive behaviors in mouse models by modulating the MAPK and BDNF signaling pathways [588]
This comes after several prior warnings
