estradiol patch and tirzepatide Menopause as a Critical Turning Point in Lipedema: The Estrogen Receptor Imbalance, Intracrine Estrogen, Adipose Tissue Dysfunction Model[v1] The Case for Combining HRT

In a substudy of people with fatty liver disease (MASLD): 12 mg dose: 86% reduction in liver fat at 48 weeks 8 mg dose: 81-82% reduction in liver fat This is huge for people with type 2 diabetes, because 5-7% of people with diabetes develop fatty liver disease and liver fibrosis

3d shows that Trp 33 is conserved in human and monkey GLP-1R whereas mouse, rat and pig have a serine residue in the corresponding position

In a simplified nutshell there are 3 energy pathways in the human body: oxidative phosphorylation (burns fat) need oxygen, glycolytic system (uses glycogen) does not need oxygen, and the phosphagen system (uses PCr) does not need oxygen

Emerging data mostly acquired from the CVOTs conducted for the various GLP-1 receptor agonists now available, also suggest that they may offer renoprotection [8]