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Similar content being viewed by others Introduction Oxidative stress has been suggested as a possible etiology in a number of neurodegenerative diseases, including Alzheimers disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) 1

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Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

TMAO has been shown to trigger inflammation and senescence in endothelial cells, causing barrier disruption and subsequent interaction with neurons