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Direct Comparison Studies While large head-to-head trials specifically comparing these medications for weight loss are limited, the SUSTAIN 10 trial compared them for diabetes: SUSTAIN 10 results: Semaglutide 1mg vs

Semaglutide can reverse the HFD-induced enrichment of bacteria positively correlated with inflammatory factors, such as TNF-, IL-6, and IL-1, and can increase those bacteria that are negatively related to inflammatory factors (Feng et al., 2024)

They extracted placebo-adjusted changes in body weight and blood pressure using treatment policy estimands*