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However, higher serum levels of GBB and TML, but not TMAO or carnitine, were independently associated with cardiovascular death after adjustment for estimated glomerular filtration rate.16 L-carnitine in CVD Treatment Despite research on potential cardiovascular risks of elevated levels of carnitine or its metabolites, L-carnitine is emerging as a target for CVD prevention and treatment due to its important role in the oxidation of fatty acids and cardiac energy metabolism

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The schedule below assumes the separate-vial approach, which is also what the staggered titration is built around