Human trials using dosages up to 900mg daily have confirmed it is safe and effective at increasing vital NAD+ markers in the body
In some cases, high doses of carnitine can cause a fishy odor in sweat or breath
Evidence was reported according to the neuropsychiatric condition under investigation: cognitive disorders (dementia, Parkinsons disease), substance-use disorders, psychotic disorders, mood and anxiety disorders, and eating disorderseach subdivided into pre-clinical and mechanistic evidence, and clinical evidence, the latter reported following a hierarchy of evidence (that is, meta-analyses, clinical trials, observational studies, case series)
To date, no randomized controlled trials have investigated the use of carglumic acid for the treatment of hyperammonaemia in patients with organic acidurias, presumably because of the rarity of the disorder