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For reference, the brain accounts for roughly 20 percent of the bodys total energy consumption
If a patient has lost 8 to 10% body weight on liraglutide and reached their clinical target (normalized HbA1c, resolved sleep apnea, improved mobility), the additional weight loss from semaglutide may not justify the cost and re-escalation burden
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They're a useful backup, especially on nausea days when whole foods feel like too much
if your antidepressant also causes nausea, these effects may feel amplified initially
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